New publication of COSM group : “Palladium(II) Coordination with Polyazacycloalkanes”
Nathalie Le Bris*, Julie Pineau, Luís M. P. Lima and Raphaël Tripier*
DOI: 10.1016/j.ccr.2021.214343
In view of the growing interest of palladium(II) for medical applications and the important role of polyamines in exploiting its properties, this review combines the published literature on the coordination of Pd(II) with small polyazacycloalkanes such as 1,4,7-triazacyclononane, 1,5,9-triazacyclododecane, cyclen, cyclam, as well as their derivatives or close scaffolds such as pyclen. Finally, the rare examples of the use of aza-ligands with 103Pd and 109Pd radioisotopes for therapeutic purposes are also presented.