New publication of COSM group : “Design of Polyazamacrocyclic Gd3+ Theranostic Agents Combining Magnetic Resonance Imaging and Two-Photon Photodynamic Therapy”
Laura Abad Galán, Nadège Hamon, Christophe Nguyen, Enikő Molnár, János Kiss, Jonathan Mendy, Kamel Hadj-Kaddour, Mélanie Onofre, György Trencsényi, Cyrille Monnereau, Maryline Beyler, Gyula Tircsó, Magali Gary-Bobo, Olivier Maury, Raphaël Tripier
DOI: https://doi.org/10.1039/D0QI01519A
New “all-in-one” theranostic systems, combining a magnetic resonance imaging contrast agent with a biphotonic photodynamic therapy photosensitiser generating cytotoxic singlet oxygen were successfully developed and characterized. They are based on well know azamacrocycles, tacn and pyclen, regiospecifically functionalised by two-photon PDT π-conjugated dibromobenzene-picolinate photosensitisers and acetate, able to complex gadolinium(III) and allow an MRI signal.